Katja Piironen

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BACKGROUND Treating hyperglycemia in acute ischemic stroke may be beneficial, but knowledge on its prognostic value and optimal target glucose levels is scarce. We investigated the dynamics of glucose levels and the association of hyperglycemia with outcomes on admission and within 48 h after thrombolysis. METHODS We included 851 consecutive patients with(More)
BACKGROUND AND PURPOSE Numerous contraindications included in the license of alteplase, most of which are not based on scientific evidence, restrict the portion of patients with acute ischemic stroke eligible for treatment with alteplase. We studied whether off-label thrombolysis was associated with poorer outcome or increased rates of symptomatic(More)
BACKGROUND Thrombolysis of ischemic stroke patients presenting with mild symptoms is controversial. AIM We aimed to describe the clinical outcome and frequency of infarcts and symptomatic intracerebral hemorrhages on follow-up imaging of such thrombolysis-treated patients. METHODS Our cohort included 1398 consecutive ischemic stroke patients treated(More)
BACKGROUND A part of ischemic stroke patients score 0 on the National Institutes of Health Stroke Scale (NIHSS) within 24 h following thrombolysis. Their clinical characteristics and long-term outcome are poorly studied. We report a single-center assessment of such patients. METHODS The cohort comprises 874 consecutive patients from the Helsinki Stroke(More)
Thrombolysis with tissue plasminogen activator is the mainstay in the treatment of acute stroke. Reducing the delay of thrombolysis treatment improves patient prognosis and reduces the incidence of complications. Variable telestroke regimens have improved the availability of stroke thrombolysis, especially in rural settings, where neurologists are not(More)
Hyperglycemia (HG), a common phenomenon in all types of acute strokes, is increasingly considered as a potential therapeutic target in ischemic stroke because there is now strong evidence that high glucose levels are independent predictors of larger infarct size, poor clinical outcome, and higher risk of mortality.1 In the past few years this has led many(More)
2. Safety objectives a. Compare hypothermia and standard care with regard to the incidence of fatal intracerebral hemorrhage (ICH), nonfatal symptomatic hemorrhage, infections, hemodynamically significant cardiac arrythmias, severe disturbance of electrolytes and fluid balance, thrombocytopenia, and/or serious adverse events until discharge or 14 days(More)
BACKGROUND AND PURPOSE Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. METHODS Patients were randomized 1:1 to mild hypothermia (35°C) or to standard stroke unit care within 6 hours of(More)
STUDY OBJECTIVE The necessity for rapid administration of intravenous thrombolysis in patients with acute ischemic stroke may lead to treatment of patients with conditions mimicking stroke. We analyze stroke patients treated with intravenous thrombolysis in our center to characterize cases classified as stroke mimics. METHODS We identified and reviewed(More)
Hyperglycemia (HG), a common phenomenon in all types of acute strokes, is increasingly considered as a potential therapeutic target in ischemic stroke because there is now strong evidence that high glucose levels are independent predictors of larger infarct size, poor clinical outcome, and higher risk of mortality.1 In the past few years this has led many(More)
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