Katja Perdan-Pirkmajer

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Astrocytes have a key role in the clearance and inactivation of histamine in the adult central nervous system, but transporters which mediate histamine uptake into astrocytes have not been fully characterized. We therefore investigated the kinetic and molecular characteristics of histamine uptake into cultured adult rat astrocytes. [(3)H]-histamine was(More)
Histaminergic signalling constitutes an attractive target for treatment of neuropsychiatric disorders. One obstacle to developing new pharmacological options has been failure to identify putative specific histamine transporter responsible for histamine clearance. Although high-affinity histamine uptake was detected in neonatal cortical astrocytes, its(More)
Background The neurotransmitter histamine is synthesized from his-tidine in histaminergic neurons. Later on it is taken up into synaptic vesicles by the vesicular monoamine transporter 2 and released into the synaptic cleft upon depo-larization stimuli. The released neurotransmitter is metabolised by the enzyme histamine N-methyltransfer-ase (HNMT)(More)
Background Histamine is a double-protonated molecule with corresponding pK a values of 5.8 and 9.4. Therefore, at physiological pH, histamine exists as an equilibrium mixture of tautomeric cations: the monocation making up 96%, the dication only 3% and the rest being nonprotonated hista-mine. As a protonated molecule histamine most probably uses a carrier(More)
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