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Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
TLDR
It is found that genes active in brain have accumulated more changes on the human than on the chimpanzee lineage, and patterns suggestive of positive selection on sequence changes as well as expression changes are seen.
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Structure of the forkhead domain of FOXP2 bound to DNA.
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The Origin of Planetary Impactors in the Inner Solar System
Insights into the history of the inner solar system can be derived from the impact cratering record of the Moon, Mars, Venus, and Mercury and from the size distributions of asteroid populations. Old…
Insulinoma-Associated 1 Has a Panneurogenic Role and Promotes the Generation and Expansion of Basal Progenitors in the Developing Mouse Neocortex
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Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brain
TLDR
It is suggested that concerted changes in a relatively small number of interacting TFs may coordinate major gene expression differences in human and chimpanzee brain.
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Rapid sequence and expression divergence suggest selection for novel function in primate-specific KRAB-ZNF genes.
TLDR
Data indicate that a substantial fraction of the recently evolved primate-specific KRAB-ZNF gene duplicates have acquired novel functions that may possibly define novel regulatory pathways and suggest an active ongoing selection for regulatory diversity in primates.
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Gain, Loss and Divergence in Primate Zinc-Finger Genes: A Rich Resource for Evolution of Gene Regulatory Differences between Species
TLDR
During primate evolution the most extensive re-shaping of the KZNF repertoire, including most gene additions, pseudogenizations, and structural changes occurred within the subfamily homininae.
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A comprehensively molecular haplotype-resolved genome of a European individual.
TLDR
The most complete haplotype-resolved genome to date, "Max Planck One" (MP1), is generated by fosmid pool-based next generation sequencing, providing the foundation to understand that the distinction of molecular haplotypes is essential to resolve the (inherently individual) biology of genes, genomes, and disease.
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Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens
TLDR
A meta-analysis of multiple published and new transcriptomes identified key host genes and pathways that respond to phylogenetically diverse pathogens, representing an important source for future functional studies as well as offering new routes to identify or generate pathogen resilient honey bee stocks.
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The role of gene regulatory factors in the evolutionary history of humans.
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