Katja J. Geißler

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BACKGROUND Receptor tyrosine kinases (RTKs) participate in a multitude of signaling pathways, some of them via the small G-protein Ras. An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras. PRINCIPAL FINDINGS We can now demonstrate that the activation of Ras requires, in addition, the(More)
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