Katja J. Geißler

Learn More
The neurofibromatosis type 2 gene product merlin is known to provoke gliogenic tumors as a result of its mutagenic loss. Merlin's physiological anti-mitogenic function makes it unique among its ezrin-radixin-moesin (ERM) family members. Although ERM proteins and merlin are known to be expressed in glial cells of the peripheral nervous system and CNS, the(More)
Spinal cord injury (SCI) results in a pathophysiology characterized by multiple locomotor and sensory deficits, resulting in altered nociception and hyperalgesia. SCI triggers an early and prolonged inflammatory response, with increased interleukin-1beta levels. Transient changes are observed in subunit populations of the transcription factor nuclear(More)
BACKGROUND Receptor tyrosine kinases (RTKs) participate in a multitude of signaling pathways, some of them via the small G-protein Ras. An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras. PRINCIPAL FINDINGS We can now demonstrate that the activation of Ras requires, in addition, the(More)
Chronic myelomonocytic leukemia patients with RAS pathway mutations show high in vitro myeloid colony formation in the absence of exogenous growth factors We read with great interest the article by Akutagawa et al. 1 in this journal in which the authors describe that PI3K inhibitors unexpectedly profoundly inhibited myeloproliferation in an(More)
Diagnostic and prognostic value of evoked potentials (EP) were studied in 5 patients with severe herpes simplex encephalitis (HSE). Latency of the third negative cortical N70 peak, elicited by median nerve stimulation, was prolonged in 3 survivors with Glasgow coma score of less than or equal to 6 (115 vs 71 ms in controls, p less than 0.05), but normal(More)
eign Affairs published nineteen articles relating to U.S. power, seven on the rise of China, and six on energy and the environment. Online—at ForeignAffairs.com—the magazine published twenty-four annotated Reading Lists, covering topics from Israeli politics to the financial crisis, twelve Letters, including one from Tehran and another from Kathmandu, and(More)
  • 1