Katja Cvan Trobec

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BACKGROUND Body wasting and cachexia change body composition and organ function, with effects on drug pharmacokinetics. The aim of this study was to investigate how cancer and cancer cachexia modify liver metabolism and renal drug elimination in rats. METHODS Nine male Wistar-Han rats received a single oral dose of midazolam and propranolol (markers of(More)
AIM To compare the performance of iohexol plasma clearance and creatinine-based renal function estimating equations in monitoring longitudinal renal function changes in chronic heart failure (CHF) patients, and to assess the effects of body composition on the equation performance. METHODS Iohexol plasma clearance was measured in 43 CHF patients at(More)
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