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Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
Coordinated migration of neurons in the developing and adult brain is essential for its proper function. The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by bindingExpand
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Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
Local endocytic events involving receptors for axon guidance cues play a central role in controlling growth cone behaviour. Yet, little is known about the fate of internalized receptors, and whetherExpand
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Disrupted neuronal trafficking in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness. MedianExpand
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Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6
Dendritic spines compartmentalize information in the brain, and their morphological characteristics are thought to underly synaptic plasticity. Here we identify copine-6 as a novel modulator ofExpand
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Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues
Many organs, such as lungs, nerves, blood and lymphatic vessels, consist of complex networks that carry flows of information, gases, and nutrients within the body. The morphogenetic patterning thatExpand
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Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
Forgetting and receptor removal The trafficking of AMPA receptors to and from the surface of postsynaptic membranes regulates synaptic strength and underlies learning and memory. Awasthi et al. foundExpand
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Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4
Summary Delivery of neurotrophins and neuropeptides via long-range trafficking of dense core vesicles (DCVs) from the cell soma to nerve terminals is essential for synapse modulation and circuitExpand
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Agrin-Signaling Is Necessary for the Integration of Newly Generated Neurons in the Adult Olfactory Bulb
In the adult forebrain, new interneurons are continuously generated and integrated into the existing circuitry of the olfactory bulb (OB). In an attempt to identify signals that regulate thisExpand
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