In male patients with Fabry disease (FD), significant age-related cerebral white matter lesions (WMLs) can be found. Although characteristic symptoms including cerebrovascular events are highly prevalent also in females with FD, cerebral structural changes have not been investigated in female FD patients yet. The authors quantified the WML load of 13 male… (More)
BACKGROUND While many "normal" subjects exhibit mild clinically detectable tremor, the extent to which this tremor is present has received little attention. OBJECTIVE To characterize the prevalence and clinical characteristics of mild, clinically detectable tremor in a multiethnic cohort of normal subjects. METHODS Normal control subjects (n=36) and… (More)
Early studies of rest cerebral metabolism and perfusion reported no association with intellectual capacity. We revisit this issue using a larger sample (N=146) and a continuous arterial spin labeling technique to measure perfusion, and working memory capacity as a measure of intellectual capacity. In the cortex, working memory capacity correlated diffusely… (More)
(1924) The auditory masking of one pure tone by another and its probable relation to the dynamics of the inner ear. (1991) Acoustical radiation from thermally stressed sea ice.
Fabry Disease (FD) is an X-linked lysosomal storage disorder (prevalence about 1 : 100 000) caused by a genetic defect associated with a lack of alpha-galactosidase A (alpha-GAL) enzyme activity. As a consequence, neutral glycosphingolipides can not be cleaved and metabolized, and accumulate in lysosomes of several tissues, particularly in vascular… (More)