The expression of growth-associated protein 43 (GAP-43), neural cell adhesion molecule (NCAM), and nerve-growth-factor-inducible large external glycoprotein (NILE) in the adult rat dorsal horn was examined at several survival times after unilateral pronase injection of the sciatic nerve. Pronase injection produces a permanent major loss of sciatic primary… (More)
Quantitative receptor autoradiography was used to evaluate potential alterations in substance P (SP) and calcitonin gene-related peptide (CGRP) binding in the L4 spinal segment of rats following unilateral poisoning of the sciatic nerve with pronase. Ten days after pronase-induced deafferentation there was a significant increase in SP and CGRP binding in… (More)
This report presents a modified use of multiple tubular retractors (that limits issues related to the sequential redocking of tubular systems) that may prove helpful in cases where a minimally invasive approach is utilized for the treatment of multilevel lumbar stenosis.
Glutamate released from primary afferents is thought to be involved in mediating spinal reflexes, nociception, and the development and consequent maintenance of hyperalgesia. The role of glutamate is dependent on the distribution and regulation of glutamate receptors in the spinal cord. Due to the numerous glutamate receptor subtypes and their differential… (More)