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BACKGROUND Mutations in SOD1 cause 13% of familial amyotrophic lateral sclerosis. In the SOD1 Gly93Ala rat model of amyotrophic lateral sclerosis, the antisense oligonucleotide ISIS 333611 delivered to CSF decreased SOD1 mRNA and protein concentrations in spinal cord tissue and prolonged survival. We aimed to assess the safety, tolerability, and(More)
We consider two-dimensional Bernoulli percolation at density p > Pc and establish the following results: 1. The probability, PN(P), that the origin is in a finite cluster of size N obeys 1 ~(p)a(p) lim ~ log PN(P)-where P~o (P) is the infinite cluster density, a(p) is the (zero-angle) surface tension, and ~(p) is a quantity which remains positive and finite(More)
BACKGROUND Unstuck and On Target (UOT) is an executive function (EF) intervention for children with autism spectrum disorders (ASD) targeting insistence on sameness, flexibility, goal-setting, and planning through a cognitive-behavioral program of self-regulatory scripts, guided/faded practice, and visual/verbal cueing. UOT is contextually-based because it(More)
Sugarcane bacilliform virus (SCBV), a badnavirus was found in sugarcane genotypes of Saccharum officinarum L., S. barberi Jesw., S. sinense Roxb., S. robustum Brand and Jesw., and Saccharum hybrids. In most of the suspected genotypes the virus was found associated with clear foliar symptoms. However, certain symptom-free clones carried the virus too. The(More)
OBJECTIVE To document the routine haemostatic variables of a group of San relocated from Namibia to South Africa. DESIGN Cross-sectional study done in two stages. SETTING Schmidtsdrif military camp in late 1990 and early 1991. SUBJECTS Healthy adult San volunteers: 31 males and 54 females from the Vasakela and Barakwena groups in 1990; 135 males from(More)
OBJECTIVES An in vivo study under well-controlled conditions was undertaken to determine the effect of Haemaccel, a colloidal plasma volume expander, on normal haemostasis. METHODOLOGY Twenty patients, who were admitted for reduction mammaplasty, were included in this study. A standardised anaesthesia protocol was followed with all patients. Ten patients(More)
The guanine base in DNA, due to its low oxidation potential, is particularly sensitive to chemical modifications. A large number of guanine lesions have been characterized and studied in some detail due to their relationship with tissue inflammations. Nevertheless, one example of these lesions is the formation of 8-nitro-guanosine, but the NMR data of this(More)