Kathy C Dowling

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Intraoperative electrophysiologic monitoring can diminish the risk of neurologic injury by enabling the detection of injury at a time when it can be reversed or minimized. This report describes a 14-year-old girl with a Chiari's malformation type I and syringomyelia who underwent a suboccipital decompression and dural patch grafting with concurrent(More)
We reviewed the results of motor evoked potential (MEP) and somatosensory evoked potential (SEP) monitoring during 116 operations on the spine or spinal cord. We monitored MEPs by electrically stimulating the spinal cord and recording compound muscle action potentials from lower extremity muscles and monitored SEPs by stimulating posterior tibial or(More)
In this study we compared the effects of propofol, small-dose isoflurane, and nitrous oxide (N(2)O) on cortical somatosensory evoked potentials (SSEP) and bispectral index (BIS) monitoring in adolescents undergoing spinal fusion. Twelve patients received the following anesthetic maintenance combinations in a randomly determined order: treatment #1:(More)
Effects of acute and chronic administration of phencyclidine (PCP) on both neocortical and subcortical visual potentials (VEPs) and on spontaneous EEGs were studied in the rhesus monkeys with permanently implanted brain electrodes. VEPs were evoked by brief single photo-stimulator flashes (0.8 pps. 10 microsec duration). Injection of PCP (0.5 to 4.0 mg/kg(More)
Effects of acute and chronic administration of phencyclidine (PCP) on EEG activities and gross behavior were studied in monkeys with electrodes implanted in the brain. Administration of PCP (2.0 or 4.0 mg/kg i.v.) in monkeys produced a biphasic pattern of inhibition and excitation of behavior during 6-8 h observation period. The inhibitory phase appeared(More)
Effects of acute and chronic administration of phencyclidine (PCP) on auditory evoked potentials (AEPs) were studied in rhesus monkeys with encephalic electrodes permanently implanted. AEPs were evoked by single clicks (1.0 pps in frequency) generated by an externally triggered audiomonitor. Single PCP injections (dose, 2.0 or 4.0 mg/kg IV) in monkeys(More)
Effects of acute and chronic administration of phencyclidine (PCP) on heart rate (HR) and respiratory rate (RR) were studied in rhesus monkeys. Acute administration of PCP (2.0 and 4.0 mg/kg i.v.) produced decrements in both HR and RR within 15 to 30 min after drug administration. Simultaneously, with this cardiorespiratory slowing, EEG tracings evidenced(More)
Improper treatment and disposal of pesticide-contaminated wastewaters raise concerns for soil and water contamination. Based on the pilot studies described here, chemical treatment via Fenton's reagent (ferrous ion plus hydrogen peroxide) of three organophosphorus insecticides in aqueous solution appears promising. Results show that the Fenton dark reaction(More)
Effects of phencyclidine (PCP) on eliciting afterdischarges (AD) by electrical stimulation of the hippocampus (HIPP), amygdala (AMY), thalamus (CM) and midbrain reticular formation (MRF) were studied in rhesus monkeys with permanently implanted encephalic electrodes. Prior to drug administration, the minimal amount of electrical stimulation for eliciting(More)
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