Kathryn T. Clayton

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Purpose: Although oral fluoropyrimidine prodrugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells(More)
Due to the specialized nature of problems in health care management, expert systems are an effective technique for developing automated decision support systems. The authors have developed four*expert systems to improve the quality of health care management services. These systems are used daily to identify potentially catastrophic or chronic cases, to(More)
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