Kathryn T. Clayton

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PURPOSE Amsalog is a derivative of 9-aminoacridine. Phase I studies using intravenous (i.v.) amsalog have shown the dose-limiting toxicity (DLT) to be phlebitis and myelosuppression. Phase II studies using a variety of schedules have shown evidence of activity in patients with large-cell lung, breast, and head and neck cancers. Preclinical studies(More)
Due to the specialized nature of problems in health care management, expert systems are an effective technique for developing automated decision support systems. The authors have developed four*expert systems to improve the quality of health care management services. These systems are used daily to identify potentially catastrophic or chronic cases, to(More)
PURPOSE Although oral fluoropyrimidine prodrugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells(More)
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