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  • Michael J. Petris, Ilia Voskoboinik, +6 authors Julian F. B. Mercer
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2002 (First Publication: 29 November 2002)
  • The Menkes protein (MNK; ATP7A) is a copper-transporting P-type ATPase that is defective in the copper deficiency disorder, Menkes disease. MNK is localized in the trans-Golgi network and transportsContinue Reading
  • Yan Guo, Kathryn Smith, Michael J. Petris
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 2004 (First Publication: 5 November 2004)
  • Cisplatin is a highly effective cancer chemotherapy agent. However, acquired resistance currently limits the clinical utility of this drug. The human high affinity copper importer, hCtr1, and itsContinue Reading
  • Yan Guo, Kathryn Smith, Jaekwon Lee, Dennis J. Thiele, Michael J. Petris
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Publication: 23 April 2004)
  • Copper uptake and subsequent delivery to copper-dependent enzymes are essential for many cellular processes. However, the intracellular levels of this nutrient must be controlled because of itsContinue Reading
  • Olive Lennon, Rose Galvin, Kathryn Smith, Catherine Doody, Catherine Blake
  • Medicine
  • European journal of preventive cardiology
  • 2014 (First Publication: 1 August 2014)
  • Background and purpose Secondary prevention in ischaemic stroke and transient ischaemic attack (TIA) is dominated by pharmacological interventions with evidence for non-pharmacological interventionsContinue Reading
  • B Kim, Kathryn Smith, Carisa K. Meagher, Michael J. Petris
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2002 (First Publication: 15 November 2002)
  • Copper is an essential co-factor for several key metabolic processes. This requirement in humans is underscored by Menkes disease, an X-linked copper deficiency disorder caused by mutations in theContinue Reading