Kathryn S. Doornbos

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Iron is an essential nutrient for most bacterial pathogens, but is restricted by the host immune system. Mycobacterium tuberculosis (Mtb) utilizes two classes of small molecules, mycobactins and carboxymycobactins, to capture iron from the human host. Here, we show that an Mtb mutant lacking the mmpS4 and mmpS5 genes did not grow under low iron conditions.(More)
Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb uses the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT), which induces necrosis by an unknown mechanism. Here we show that TNT gains access to the cytosol of(More)
111 attendees took advantage of the opportunity to share their diverse experiences and knowledge in the relaxing atmosphere of the Gulf Coast. Pete Burrows, director of the Immunology Graduate Theme says, " The retreat provides an informal setting for students and postdocs to present their research and discuss it with the Microbiology faculty. " The retreat(More)
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