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Hyperinsulinemia increases sympathetic nerve activity and contributes to cardiovascular dysfunction in obesity and diabetes. Neurons of the hypothalamic paraventricular nucleus (PVN) regulate sympathetic nerve activity through mono- and poly-synaptic connections to preganglionic neurons in the spinal cord. The purpose of the present study was to determine(More)
Recombinant simian virus 5 (rSV5) mutants containing substitutions in the M-F intergenic region were generated to determine the effect of increased readthrough transcription on the paramyxovirus growth cycle. We have previously shown, using an SV5 dicistronic minigenome, that replacement of the 22-base M-F intergenic region with a foreign sequence results(More)
Synaptic plasticity, or the change in weight of the connections between cells, is a key mechanism underlying the brain's spatial representation and navigation functions. Experimentalists have shown that grid cells in the medial entorhinal cortex fire in hexagonal patterns within an environment, or set of visual cues. Grid cells provide the input for place(More)
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