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The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development
TLDR
The results suggest suppression of senseless overexpression by mutations in Caf1 is mediated by participation of Caf1 in PRC2- mediated silencing, and mutant phenotypes confirm that Caf1-mediated silencing is vital to Drosophila development. Expand
Senseless is required for pupal retinal development in Drosophila
TLDR
The function of senseless is analyzed during pupal retinal development and it is found that senseless is required for recruitment of both cone and pigment cells, the pupal‐derived ommatidial support cells, and is both necessary and sufficient for interommatidials bristle development. Expand
Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate
TLDR
New evidence is provided that lateral inhibition, but not ro, is required for the initial selection of a single R8 precursor, and results support a new model for R8 selection in which lateral inhibition establishes a transient pattern of selected R8s that is permanently reinforced by a repressive bistable loop between sens and ro. Expand
SD-OCT and autofluorescence characteristics of autoimmune retinopathy
TLDR
Patients with AIR can present with structural abnormalities that are detectable by fundus AF and SD-OCT, and these imaging modalities may be useful in establishing the diagnosis of this rare disease, monitoring disease progression and evaluating response to therapy. Expand
Tubulointerstitial nephritis and uveitis
TLDR
This review summarizes key historical publications that identified and defined the syndrome, and more recent literature that reveal the importance of urinary &bgr;2-microglobulin testing and kidney biopsy in the diagnostic evaluation of patients with TINU. Expand
Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography.
TLDR
SD-OCTA algorithms are robust enough to detect changes and can provide a novel diagnostic index of disease for uveitis subjects and demonstrates significantly lower capillary density and complexity. Expand
Retinal Pigment Epithelial Detachments in Age-Related Macular Degeneration: Classification and Therapeutic Options
TLDR
The historical PEDs subtypes are reviewed, recent insights into PED pathogenesis provided by modern imaging modalities are included, and the current options for treatment are summarized. Expand
Targeting Interleukin-23 in the Treatment of Noninfectious Uveitis.
TLDR
The biology of the IL-23/IL-17 axis and its relevance to the pathogenesis of experimental and clinical uveitis are described, and the monoclonal antibody therapies targeting this pathway are reviewed. Expand
Wide-field optical coherence tomography based microangiography for retinal imaging
TLDR
OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope is reported that is clinically feasible to image functional retinal vasculature in patients, with a coverage of more than 60 degrees of retina while still maintaining high definition and resolution. Expand
Quantitative Assessment of Anterior Segment Inflammation in a Rat Model of Uveitis Using Spectral-Domain Optical Coherence Tomography
TLDR
Spectral-domain optical coherence tomography provides high-resolution images of the structural changes associated with anterior uveitis in rats and can be used to quantify inflammation longitudinally in single animals. Expand
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