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Flibanserin has preferential affinity for serotonin 5-HT(1A), dopamine D(4k), and serotonin 5-HT(2A) receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5-HT(1A) agonist, a very weak partial agonist on dopamine D(4) receptors, and a 5-HT(2A) antagonist. In vivo flibanserin binds equally to 5-HT(1A) and 5-HT(2A) receptors. However, under(More)
Rats treated directly with water or lead acetate (25 or 75 mg/kg) on postnatal days 2 through 14 were tested for the development of spontaneous activity and for locomotor responses to d-amphetamine as weanlings. The development of striatal dopamine (DA) levels, uptake, release, and the disappearance of DA after synthesis inhibition were also examined. Blood(More)
Offspring of rats exposed to water or 15 mg/kg/dy of imipramine (IMI) on gestational day 8 through 20 were examined for behavioral and neurochemical development. IMI-treated mothers gained significantly less weight during pregnancy, but the percentage giving birth, length of gestation and litter size were unaffected. Body weights of IMI-exposed offspring(More)
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