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Flibanserin has preferential affinity for serotonin 5-HT(1A), dopamine D(4k), and serotonin 5-HT(2A) receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5-HT(1A) agonist, a very weak partial agonist on dopamine D(4) receptors, and a 5-HT(2A) antagonist. In vivo flibanserin binds equally to 5-HT(1A) and 5-HT(2A) receptors. However, under(More)
Offspring of rats exposed to water or 15 mg/kg/dy of imipramine (IMI) on gestational day 8 through 20 were examined for behavioral and neurochemical development. IMI-treated mothers gained significantly less weight during pregnancy, but the percentage giving birth, length of gestation and litter size were unaffected. Body weights of IMI-exposed offspring(More)
Rats treated directly with water or lead acetate (25 or 75 mg/kg) on postnatal days 2 through 14 were tested for the development of spontaneous activity and for locomotor responses to d-amphetamine as weanlings. The development of striatal dopamine (DA) levels, uptake, release, and the disappearance of DA after synthesis inhibition were also examined. Blood(More)
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