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MOTIVATION It has long been hypothesized that incorporating models of network noise as well as edge directions and known pathway information into the representation of protein-protein interaction (PPI) networks might improve their utility for functional inference. However, a simple way to do this has not been obvious. We find that diffusion state distance(More)
Characterizing protein function is a crucial part of understanding biological systems. Here we improve protein function prediction by accounting for data quality issues inherent in protein-protein interaction (PPI) databases. To accomplish this, we incorporate confidence information into the function prediction pipeline. The model pipeline uses weighted(More)
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