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Most smokers repeatedly fail in their attempts to stop smoking because of the addictive nature of the nicotine in tobacco products. Nicotine dependence is probably mediated through the activation of multiple subtypes of neuronal nicotinic acetylcholine receptor (nAChR), among which the mesolimbic alpha(4)beta(2) subtype has a pivotal role. Here, we discuss(More)
The pharmacological properties and pharmacokinetic profile of the alpha4beta2 nicotinic acetylcholine receptor (nAChR) partial agonist varenicline provide an advantageous combination of free brain levels and functional potencies at the target receptor that for a large part explain its efficacy as a smoking cessation aid. Since alpha4beta2 and other nAChR(More)
Most smokers repeatedly fail in their attempts to stop smoking because of the addictive nature of the nicotine in tobacco products. Nicotine dependence is probably mediated through the activation of multiple subtypes of neuronal nicotinic acetylcholine receptor (nAChR), among which the mesolimbic a 4 b 2 subtype has a pivotal role. Here, we discuss the(More)
PURPOSE: Several preoperative and intraoperative risk factors have been implicated in infectious complications of immediate breast reconstruction, however the link between common postoperative sequelae and surgical site infection (SSI) remains largely anecdotal. Published rates of seroma and SSI often trend in parallel, and authors have hypothesized that(More)
days (40–1083). There were a number of surgical indications: malignancy (n=25), risk reduction (n=40), revision (n=32) and delayed reconstruction (n=8). Incision type varied; wise pattern (32), IMF (48) and transverse/vertical (20). Mean mastectomy weight was 473g (73–1679), and median implant volume: 409cc (165–620). Length of stay was 0.96 days. Four(More)
Clinical video teleconferencing (CVT) is a treatment delivery modality that can be used to provide services to clinical populations that experience barriers to accessing mental health care. Recently, home-based CVT (HBCVT) has been developed in order to deliver treatment via CVT to patients in their homes. A number of clinical considerations, including the(More)
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