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Resistance to antimalarial drugs is a public health problem worldwide. Molecular markers for drug-resistant malaria, such as pfcrt and pfmdr1 polymorphisms, could serve as useful surveillance tools. To evaluate this possibility, sequence polymorphisms in pfcrt (position 76) and pfmdr1 (positions 86, 184, 1034, 1042, and 1246) and in vitro drug sensitivities(More)
Artemisinin derivatives are first-line antimalarial drugs in Thailand. No firm evidence of clinically relevant artemisinin resistance exists. When used as monotherapy, artesunate has been associated with a high treatment failure (recrudescence) rate, which could be due to low-level artemisinin resistance. To understand the causes of recrudescence, we(More)
OBJECTIVE The objectives of this study were to determine the incidence of femur fractures in Colorado children, to assess underlying causes, to determine the prevalence and predictors of associated injuries, and to identify potentially modifiable risk factors. METHODS The study population included all Colorado residents who were aged 0 to 17 years at the(More)
INTRODUCTION Delays in appropriate treatment and unnecessary antibiotic use for urinary tract infections (UTIs) increase the risk for serious adverse events and the potential for antibiotic resistance. The purposes of this quality improvement project were to decrease emergency department laboratory result follow-up time and increase the number of patients(More)
OBJECTIVE To evaluate the child passenger safety curriculum of the Junglemobile, a traveling injury prevention program for young children. DESIGN Cross-sectional evaluation with self-controls, convenience sample. SETTING School and community events in rural Colorado, Wyoming, and western Nebraska where the Junglemobile participated for the years(More)
BACKGROUND A hemostatic monitor capable of rapid, accurate detection of clinical coagulopathy within the operating room could improve management of bleeding after cardiopulmonary bypass (CPB). The Clot Signature Analyzer is a hemostatometer that measures global hemostasis in whole blood. The authors hypothesized that point-of-care hemostatometry could(More)
OBJECTIVE To describe parental use of an Internet-based educational and emotional support system, in a regional NICU program. METHODS Baby CareLink was installed in NICUs in 4 Denver area hospitals in 2003. Parents were offered access from hospital terminals and from any other Internet access point. Data on use of the program was collected by the computer(More)
OBJECTIVE To describe parental use of an Internet-based educational and emotional support system, in a regional NICU program. METHODS Baby CareLink was installed in NICUs in 4 Denver area hospitals in 2003. Parents were offered access from hospital terminals and from any other Internet access point. Data on use of the program was collected by the computer(More)
BACKGROUND Motor vehicle crashes are the leading cause of mortality for children aged 4-14 in the United States. Many children are driven daily to school, increasing their exposure to potential injury, especially if they are not appropriately restrained. Observing the level of motor vehicle occupant restraint (MVOR) use upon school arrival could lead to(More)
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