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OBJECTIVE Prior research has suggested the possible role of oxidative stress in the pathogenesis of amyotrophic lateral sclerosis (ALS). Prospective data examining dietary antioxidants such carotenoids and vitamin C are limited. METHODS Risk of ALS associated with carotenoid and vitamin C intake was investigated in 5 prospective cohorts: the National(More)
IMPORTANCE Low serum 25-hydroxyvitamin D (25[OH]D) levels are associated with an increased risk of multiple sclerosis (MS) as well as with increased disease activity and rate of progression in clinically isolated syndromes and early MS. OBJECTIVE To assess the association between 25(OH)D and disease course and prognosis in patients with(More)
Our objective was to determine if amyotrophic lateral sclerosis (ALS) risk varies according to body mass index (BMI) captured up to three decades earlier. At baseline 537,968 females and 562,942 males in five ongoing cohorts reported height, current weight and weight at age 18/21 years. During 14-28 years of follow-up, 1153 participants developed ALS.(More)
Disease classification system increasingly incorporates information on pathogenic mechanisms to predict clinical outcomes and response to therapy and intervention. Technological advancements to interrogate omics (genomics, epigenomics, transcriptomics, proteomics, metabolomics, metagenomics, interactomics, etc.) provide widely open opportunities in(More)
BACKGROUND Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss of CDH1 expression in colorectal carcinoma might be associated with aggressive features and clinical outcome. METHODS Utilising molecular pathological epidemiology database of 689 rectal and colon cancer cases in(More)
BACKGROUND Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). OBJECTIVES We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was associated with risk of PD. METHODS We linked the U.S. Environmental Protection Agency (EPA)'s Air Toxics tract-level data with the Nurses'(More)
IMPORTANCE Amyotrophic lateral sclerosis (ALS) is a severe progressive disease that cannot be prevented or cured. Diet-derived long-chain polyunsaturated fatty acids (PUFAs) are incorporated in brain lipids and modulate oxidative and inflammatory processes and could thus affect ALS risk and progression. OBJECTIVE To examine the association between ω-6 and(More)
BACKGROUND Once atrial fibrillation (AF) progresses to sustained forms, adverse outcomes increase and treatment success rates decrease. Therefore, identification of risk factors predisposing to persistence of AF may have a significant impact on AF morbidity. METHODS AND RESULTS We prospectively examined the differential associations between traditional,(More)
PURPOSE The purpose of this qualitative study was to explore perceptions of people with diabetes about their experience of living with and managing their diabetes. METHODS This study was part of a larger study of patients with diabetes who used a novel computer portal system for access to information about diabetes and to their health care providers for(More)
BACKGROUND Multiple Sclerosis (MS) is an autoimmune disorder leading to central nervous system inflammation. Traditionally, reported MS prevalence rates in the Middle East are low. Few studies include age/sex standardization giving an unreliable estimate of regional prevalence. OBJECTIVE to determine the prevalence, incidence and characteristics of MS in(More)