Kathryn Blaschke

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DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germ line, and may be mediated by Tet (ten eleven translocation) enzymes, which convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet enzymes have(More)
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons 1. Global DNA demethylation occurs in the early embryo and the germline 2,3 and may be mediated by Tet (ten-eleven-translocation) enzymes 4–6 , which convert 5-methylcytosine (mC) to 5-hydroxymethylcytosine (hmC) 7. Tet(More)
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