Kathryn Blaschke

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DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germ line, and may be mediated by Tet (ten eleven translocation) enzymes, which convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet enzymes have(More)
Pluripotent stem cells are derived from culture of early embryos or the germline and can be induced by reprogramming of somatic cells. Barriers to reprogramming that stabilize the differentiated state and have tumor suppression functions are expected to exist. However, we have a limited understanding of what such barriers might be. To find novel barriers to(More)
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons 1. Global DNA demethylation occurs in the early embryo and the germline 2,3 and may be mediated by Tet (ten-eleven-translocation) enzymes 4–6 , which convert 5-methylcytosine (mC) to 5-hydroxymethylcytosine (hmC) 7. Tet(More)
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