• Publications
  • Influence
Ref‐1/Ape is critical for formation of the hypoxia‐inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene
TLDR
DNA affinity‐precipitation analyses showed that Ref‐1/Ape was part of the multiprotein transcriptional complex forming on a 64‐mer sequence encompassing a minimal hypoxic response element of the VEGF gene's hypoxia‐induced gene expression HIF‐1. Expand
Oxidants in signal transduction: impact on DNA integrity and gene expression
TLDR
Modeling this effect by replacing the targeted guanine with an abasic site increased incorporation of HIF‐1 and the bi‐functional DNA repair enzyme and transcriptional coactivator, Ref‐1/Ape1, into the transcriptional complex and engendered more robust reporter gene expression. Expand
Preferences for oral and parenteral antitumor therapy: A survey of 260 patients with metastatic breast cancer
TLDR
This study evaluated preferences for oral chemotherapy (OC) vs IV chemotherapy (IC) and oral (OE) vs IM endocrine therapy (IME) and found that oral therapy is preferable, because of the perceived inconvenience and discomfort of parenteral therapy (PT). Expand
Medical oncologists’ clinical experiences and comfort levels with 20 recently approved agents.
TLDR
Variation in MO use of recently approved drugs is multifactorial, and the suboptimal treatment options available to oncologists with limited clinical experience are varied. Expand
Abstract P1-18-23: Evaluating the potential utility of presenting breast cancer clinical investigator estimates for numeric treatment benefit and recommendations for the use of two anti-HER2 adjuvant
TLDR
Evaluating the potential utility of presenting breast cancer clinical investigator estimates for numeric treatment benefit and recommendations for the use of two anti-HER2 adjuvant therapies: HER RISK concludes that there was a clear relationship between the estimated benefit of therapy and its use. Expand
Is adjuvant oxaliplatin (Ox) overutilized in colon cancer (CC)? 408 cases from the practices of 102 oncologists.
TLDR
This study documents current use of adjuvant chemotherapy and physician perceptions about these decisions, and provides evidence that RS may specifically predict the value of Ox. Expand
Prioritizing Content in Continuing Hematologic Oncology Education: A Survey of 51 Clinical Investigators
TLDR
This pilot project demonstrates that CIs regularly evaluate patients previously managed by CBOs and also provide long-distance second opinions by email and phone that in some instances result in divergent recommendations. Expand
The Use of An Online Case Database to Obtain Clinical and Psychosocial Information Related to the Selection of and Experience with Initial Systemic Therapy for Multiple Myeloma.
TLDR
A web-based instrument allowed rapid and efficient collection of relevant information and provided a snapshot of newly diagnosed MM in community-based practice and revealed several potential “knowledge gaps,” represented by heterogeneity in the selection of initial systemic therapy and the lack of adequate staging and prognostic information, including cytogenetics. Expand
Tolerance and Response to Initial Systemic Therapy In Older Patients with Follicular Lymphoma (FL): Observations From 186 Unselected Recent Cases In the Practices of US-Based Medical Oncologists
TLDR
The data suggest that MOs are able to individualize SATs for older patients and match the short-term outcomes and tolerability of the therapies selected for younger patients, as well as the impact of age on treatment selection and resultant outcomes. Expand
...
1
2
...