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Genetically encoded Ca2+ indicators in cardiac myocytes.
Genetically encoded Ca(2+) indicators constitute a powerful set of tools to investigate functional aspects of Ca(2+) signaling in isolated cardiomyocytes, cardiac tissue, and whole hearts. Here, we… Expand
The cardiac sodium-calcium exchanger NCX1 is a key player in the initiation and maintenance of a stable heart rhythm.
AIMS The complex molecular mechanisms underlying spontaneous cardiac pacemaking are not fully understood. Recent findings point to a co-ordinated interplay between intracellular Ca(2+) cycling and… Expand
Morphologically Homogeneous Red Blood Cells Present a Heterogeneous Response to Hormonal Stimulation
Red blood cells (RBCs) are among the most intensively studied cells in natural history, elucidating numerous principles and ground-breaking knowledge in cell biology. Morphologically, RBCs are… Expand
Cardiac remodeling in Gαq and Gα11 knockout mice.
- Kathrina Wiesen, Elisabeth Kaiser, +9 authors L. Kaestner
- International journal of cardiology
BACKGROUND Although both Gαq- and Gα11-protein signaling are believed to be involved in the regulation of cardiac hypertrophy, their detailed contribution to myocardial function remains elusive. … Expand
Lysophosphatidic Acid Signalling in Red Blood Cells
Red blood cells are among the most intensively studied cells in natural history, elucidating numerous principles and ground-breaking knowledge in cell biology. Morphologically, red blood cells are… Expand
Novel Roles of Gq-Dependent Signal Transduction for Cardiac Pacemaking and Cardiac Impulse Propagation Studied by Gq-KO and a DREADD
Many processes in the heart are modulated via G protein-coupled receptors (GPCRs). While the role of Gi-, Go- and Gs-proteins for pacemaking, impulse propagation and the myocardial function are well… Expand
Alterations of Membrane Currents, Contractility and Calcium Signaling in Gq/G11 Single and Double Ko Mice
In contrast to its role in pathophysiology very little is known about the role of the Gq/G11 signaling cassette in the physiology of cardiac myocytes. We have generated transgenic mice combining a… Expand
Research May 9 , 2014 Application of GECI in the Heart
Conceptual Considerations Excitation–contraction coupling is an essential mechanism responsible for the blood-pumping function of the heart. In cardiac myocytes, repetitive Ca cycling translates… Expand
Excision of the Cacnb2 Gene in Mice Results in Augmented SR-Ca Release and Impaired Cardiac Function In Vivo
In mammalian cardiac myocytes, L-type Ca channels comprise at least the pore-forming Cav1.2α1 and an auxiliary Cavs2 subunit. Since Cavs2 null mice die at embryonic day 10.5, we used our recently… Expand
GαQ/Gα11 Modulate Aldosterone Mediated Electrical Remodeling and Ca2+ Handling Alterations in Ventricular Myocytes
Aldosterone stimulates unidirectional sodium transport across renal epithelial cells, thereby regulating blood volume and pressure. Clinical and experimental studies have linked hyperaldosteronism… Expand