Kathrin S Schmidt

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Aptamers are powerful candidates for molecular imaging applications due to a number of attractive features, including rapid blood clearance and tumor penetration. We carried out structure-activity relationship (SAR) studies with the Tenascin-C binding aptamer TTA1, which is a promising candidate for application in tumor imaging with radioisotopes. The aim(More)
Stilbenes and zeranol are nonsteroidal estrogenic growth promoters which are banned in the European Union (EU) for use in food-producing animals by Council Directive 96/22/EC. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the screening and confirmation of stilbenes (diethylstilbestrol, dienestrol, hexestrol) and(More)
The pharmacokinetic properties of an aptamer against the tumour-marker protein tenascin-C have recently been successfully improved by the introduction of locked nucleic acids (LNAs) into the terminal stem of the aptamer. Since it is believed that this post-SELEX optimization is likely to provide a more general route to enhance the in vitro and in vivo(More)
Anabolic steroids are banned from use in food-producing animals in the EU (Council Directive 96/22/EC). To control the zero-tolerance concept a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the screening and confirmation of most of the relevant natural and synthetic estrogenic and androgenic steroids in bovine muscle was developed and(More)
Anabolic steroids are banned from use in food-producing animals in the European Union (Council Directive 96/22/EC). To control the zero-tolerance concept, an LC-MS/MS method for the screening and confirmation of most of the relevant natural and synthetic estrogenic and androgenic steroids in bovine and porcine blood plasma was developed and validated. The(More)
Within the framework of the German National Residue Control Plan a specific number of samples of animal origin have to be analysed for natural and synthetic steroids each year. As a measure of external quality control of the methods applied in routine analysis a proficiency test was carried out. To this end, in-house reference material containing incurred(More)
A sensitive and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method allowing the rapid screening and confirmation of thyreostatic drugs in bovine blood plasma was developed and validated according to Commission Decision 2002/657/EC, chapter 3.1.3 "alternative validation", by applying a matrix-comprehensive in-house validation concept.(More)
A sensitive and robust liquid chromatography-tandem mass spectrometry method allowing the rapid screening and confirmation of ten synthetic corticosteroids in bovine and porcine muscle tissue was developed and validated. The validation was conducted according to Commission Decision 2002/657/EC, Sect. 3.1.3 ("Validation according to alternative models"), by(More)
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