Kathrin Leppek

Publications13
h-index6
Citations758
Highly Influential Citations56
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Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs
Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals. The degradation of TNF-α mRNA is critical for restricting TNF-α synthesis and involves a constitutive decay… Expand
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The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity
During eukaryotic evolution, ribosomes have considerably increased in size, forming a surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an interface for yet… Expand
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Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm
In mammalian cells, AU-rich elements (AREs) are well known regulatory sequences located in the 3′ untranslated region (UTR) of many short-lived mRNAs. AREs cause mRNAs to be degraded rapidly and… Expand
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Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review, we discuss the current mechanistic… Expand
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An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins
Determining the composition of messenger ribonucleoprotein (mRNP) particles is essential for a comprehensive understanding of the complex mechanisms underlying mRNA regulation, but is technically… Expand
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A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin.
The constitutive decay element (CDE) of tumor necrosis factor α (TNF-α) mRNA (Tnf) represents the prototype of a class of RNA motifs that mediate rapid degradation of mRNAs encoding regulators of the… Expand
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Protein synthesis and translational control: at eye level with the ribosome
At the EMBO Conference on ‘Protein Synthesis and Translational Control’ held in Heidelberg in September 2011, scientists shared their latest findings on the structure and function of the ribosome,… Expand
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Author Correction: Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
The legend of Figure 1 has been modified to remove misleading referencing to evolution. The title of the legend has been modified from ‘Evolutionary expansion of eukaryotic 5’ UTR lengths’ to… Expand
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VELCRO-IP RNA-seq explores ribosome expansion segment function in translation genome-wide
Roles for ribosomal RNA (rRNA) in gene regulation remain largely unexplored. With hundreds of rDNA units scattered across multiple chromosomal loci, it is not possible to genetically modify rRNA in… Expand
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An rRNA variant to deal with stress
Bacteria have previously been assumed to cope with environmental stress by tuning their total number of active ribosomes. Instead, a study in this issue of Nature Microbiology shows that from a… Expand
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