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Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism
Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is unknown how glucose utilization and glycolysis are adapted to the different axonal energy demands. SpikingExpand
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  • Open Access
Monitoring ATP dynamics in electrically active white matter tracts
In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated axons are compatible with underlying energy deficits. However, it is presently impossible toExpand
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  • Open Access
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin. Despite the relevance of the peripheralExpand
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  • Open Access
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction
Myelination of axons facilitates rapid impulse propagation in the nervous system. The axon/myelin-unit becomes impaired in myelin-related disorders and upon normal aging. However, the molecular causeExpand
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Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary toExpand
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Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons
Proteolipid protein (PLP) is the most abundant integral membrane protein in central nervous system (CNS) myelin. Expression of the Plp‐gene in oligodendrocytes is not essential for the biosynthesisExpand
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Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin‐2
Deficiency of the major constituent of central nervous system (CNS) myelin, proteolipid protein (PLP), causes axonal pathology in spastic paraplegia type‐2 patients and in Plp1null‐mice but isExpand
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Knockout of Silent Information Regulator 2 (SIRT2) Preserves Neurological Function after Experimental Stroke in Mice
Sirtuin-2 (Sirt2) is a member of the NAD+-dependent protein deacetylase family. Various members of the sirtuin class have been found to be involved in processes related to longevity, regulation ofExpand
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Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking
Protein zero (P0) is the major structural component of peripheral myelin. Lack of this adhesion protein from Schwann cells causes a severe dysmyelinating neuropathy with secondary axonal degenerationExpand
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Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
Pelizaeus–Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model of PMD with perturbed blood–brain barrier integrity, cholesterol supplementation promotes myelin membraneExpand
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