Kathleen Schlör

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The cardiovascular effects of opioid peptides have been studied. Leucine-enkephalin (Leu-ENK) produced blood pressure (BP) increases following administration into the lateral brain ventricles (i.v.t.), into the cisterna magna (i.c.i.), and following intravenous (i.v.) administration. Heart rate (HR) increases were observed following all routes of(More)
1. Stimulation within the amygdaloid complex elicited two different behavioural and cardiovascular patterns of response. In the awake animal stimulation of the magnocellular part of the basal amygdala resulted in a defence reaction. Stimulation parameters eliciting only the first stage of this behaviour induced a moderate tachycardia and a shortlasting(More)
Baroreceptor control of heart rate was studied in 14 unanaesthetized cats during rest and arousal induced by either electrical stimulation of the central nucleus of the amygdala or by natural stimuli. The baroreceptor reflex was elicited by i.v. injections of angiotensin II and the sensitivity of the vagal component of the reflex expressed as the regression(More)
Metachromatic leukodystrophy (MLD) is an autosomal recessive progressive demyelination disorder caused by the deficiency of arylsulfatase A (ASA). However, there exist individuals with low ASA activity without clinical symptoms. This state is described as ASA pseudodeficiency (PD). A number of patients with low ASA activity and various neuropsychiatric(More)
Experiments were performed in chronically operated cats first awake and thereafter anesthetized with pentobarbitone, 16-20 mg/kg i.v. Stimulation of the central amygdala in awake cats elicited an arousal reaction seen in cortical and hippocampal EEG, and in muscle activity of dorsal neck muscles. Concomitantly therewith were autonomic system reactions(More)
Auditory cortical evoked potentials of 20 schizophrenic patients with an acute exacerbation of the illness were investigated before neuroleptic medication and after remission of the acute symptoms, and compared with healthy controls matched for sex and age. Additionally, tests were conducted in 40 healthy volunteers to ascertain whether psychoticism or(More)
Bipolar electrical stimulations of the rostral hippocampus and of the amygdala were performed at irregular intervals in wakeful unrestrained cats via chronically implanted glass-insulated stainless steel electrodes. The excitability of the stimulated tissue remained unchanged during the whole investigation period of six months up to one and a half years, as(More)
1. The cardiovascular effects of enkephalins have been tested in normotensive Wistar-Kyoto rats. Methionine-enkephalin and leucine-enkephalin increased blood pressure and heart rate after infusion into the brain ventricles. 2. After intravenous injection, blood pressure was increased by methionine-enkephalin and leucine-enkephalin, but heart rate was(More)
Intravenous injections of gammahydroxybutyric acid (GHBA) (150-200 mg/kg) induce desynchronized sleep (DS) in the cat. This was shown by recording the EEG, eye-movements, the neck EMG, heart-rate and arterial pressure. The decreases in arterial pressure were not different from those recorded during naturally occurring DS. GHBA, given at doses above 200(More)