We previously reported the design of a library of de novo proteins targeted to fold into 4-helix bundles. 1 The library was created using a " binary code " strategy in which the sequence locations of polar and nonpolar amino acids were specified explicitly, but the identities of these side chains were varied extensively. Combinatorial diversity was made… (More)
Carbon monoxide binding was studied in a collection of de novo heme proteins derived from combinatorial libraries of sequences designed to fold into 4-helix bundles. The design of the de novo sequences was based on the previously reported "binary code" strategy, in which the patterning of polar and nonpolar amino acids is specified explicitly, but the exact… (More)
Avasarala, J. (2014). Inadequacy of clinical trial designs and data to control for the confounding impact of race/ethnicity in response to treatment for multiple sclerosis. measures of psychosocial issues and health behavior should be added to electronic health records.
In September 2011, scientists announced new experimental findings that would not only threaten the conduct and publication of influenza research, but would have significant policy and intelligence implications. The findings presented a modified variant of the H5N1 avian influenza virus (hereafter referred to as the H5N1 virus) that was transmissible via… (More)
In this paper, I describe the challenges of using Big Data approaches in assessing security threats from the life sciences.