Kathleen M. Curran

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BACKGROUND Photodynamic therapy (PDT) is a treatment modality for a range of diseases including cancer. The BF(2)-chelated tetraaryl-azadipyrromethenes (ADPMs) are an emerging class of non-porphyrin PDT agent, which have previously shown excellent photochemical and photophysical properties for therapeutic application. Herein, in vivo efficacy and mechanism(More)
UNLABELLED The assessment of regional skeletal metabolism using (18)F-fluoride PET ((18)F-PET) requires segmentation of the tissue region of interest (ROI). The aim of this study was to validate a novel approach to define multiple ROIs at the proximal femur similar to those used in dual x-ray absorptiometry. Regions were first drawn on low-dose CT images(More)
—The purpose of this paper is to register ex-vivo cardiac diffusion tensor images using affine transformations and the preservation of the principal direction reorientation strategy. We have successfully registered cardiac DTI and compared five different similarity measures: relative anisotropy difference , modulus difference, tensor difference, normalized(More)
  • C S Gil, N Colgan, A J Bakermans, B J Van Nierop, G J Strijkers, H C Van Assen +1 other
  • 2010
Introduction Diffusion tensor imaging (DTI) [2] allows the visualization of diffusion of water in tissue. For the last decade, this powerful imaging technique has been mainly applied in neurological studies where fiber tracts can be analyzed revealing white matter connectivity. Extensive work on DTI brain registration was developed with the goal of(More)
BACKGROUND Nystagmus in patients with multiple sclerosis (MS) is generally attributed to brainstem disease. Lesions in other regions may result in nystagmus. The identification of these other sites is enhanced by using 3-Tesla magnetic resonance imaging (3TMRI) due to increased signal-to-noise ratio. OBJECTIVE We sought to evaluate the distribution of(More)
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