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  • Yanti Octavia, Carlo Gabriele Tocchetti, Kathleen L. Gabrielson, Stefan Janssens, Harry J.G.M. Crijns, An L. Moens
  • Medicine
  • Journal of molecular and cellular cardiology
  • 2012 (First Publication: 1 June 2012)
  • The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of cardiotoxicity. It has been calculated that approximately 10% of patients treated with doxorubicin orContinue Reading
  • Thomas Sussan, Tirumalai Rangasamy, +13 authors Shyam Biswal
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 2009 (First Publication: 6 January 2009)
  • Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with noContinue Reading
  • G. Christian Baldeviano, Jobert G. Barin, +7 authors Daniela Čiháková
  • Biology, Medicine
  • Circulation research
  • 2010 (First Publication: 1 April 2010)
  • RATIONALE One-third of myocarditis cases progresses to dilated cardiomyopathy (DCM), but the mechanisms controlling this process are largely unknown. CD4(+) T helper (Th)17 cells have been implicatedContinue Reading
  • Eiki Takimoto, Hunter C. Champion, +8 authors David A. Kass
  • Medicine, Chemistry
  • The Journal of clinical investigation
  • 2005 (First Publication: 2 May 2005)
  • Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide synthase-3 (NOS3) plays aContinue Reading
  • Norimichi Koitabashi, Djahida Bedja, +5 authors David A. Kass
  • Biology, Medicine
  • Circulation research
  • 2009 (First Publication: 2 July 2009)
  • Cardiac myocyte targeted MerCreMer transgenic mice expressing tamoxifen-inducible Cre driven by the alpha-myosin heavy chain promoter are increasingly used to control gene expression in the adultContinue Reading