Kathleen L. Tober

Learn More
Skin cancer incidence and mortality are higher in men compared to women, but the causes of this sex discrepancy remain largely unknown. Ultraviolet light exposure induces cutaneous inflammation and neutralizes cutaneous antioxidants. Gr-1 + CD11b + myeloid cells are heterogeneous bone marrow-derived cells that promote inflammation-associated carcinogenesis.(More)
ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) and phosphatase and tensin homologue deleted on chromosome ten (PTEN). Since ΔNp63α has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against(More)
Epidemiological studies support a link between cumulative sun exposure and cutaneous squamous cell carcinoma (SCC) development. However, the presumed effects of extended ultraviolet light B (UVB) exposure on tumorigenesis in the sexes have not been formally investigated. We examined differences in ultimate tumorigenesis at 25 weeks in mice exposed to UVB(More)
Because of the ever-increasing incidence of ultraviolet light B (UVB)-induced skin cancer, considerable attention is being paid to prevention through the use of both sunscreens and after sun treatments, many of which contain antioxidants. Vitamin E is included as an antioxidant in many sunscreens and lotions currently on the market. Studies examining the(More)
Slug (Snai2), a highly conserved transcriptional repressor important in epithelial-mesenchymal transformation (EMT) in development, has also been implicated in EMT-like processes during tumor progression (Hemavathy et al., 2000). Slug null mice chronically exposed to ultraviolet radiation (UVR) develop a lower skin tumor burden than wild type mice, with(More)
  • 1