Kathleen Kohut

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Background:Invasive lobular breast cancer (ILC) and lobular carcinoma in situ (LCIS) are characterised by loss of E-cadherin expression. However germline CDH1 mutations are rare in cases of ILC with no family history of hereditary diffuse gastric cancer (HDGC) and have not been described in women with LCIS.Methods:We screened the CDH1 gene in 50 cases of(More)
This article is an executive summary of the Association for Professionals in Infection Control and Epidemiology's elimination guide for mediastinitis surgical site infections. Infection preventionists are encouraged to obtain the original, full-length elimination guide for more thorough coverage of mediastinitis surgical site infection prevention.
To the Editor : In the 16 years since the discovery of BRCA1 and BRCA2, only one de novo mutation in the BRCA1 gene and four de novo mutations in the BRCA2 gene have been reported in the literature (1–5). No systematic study of de novo mutation prevalence has been performed. This is surprising, given that the rates of de novo mutations can be as high as(More)
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