Kathleen Friedrich

Learn More
Stat (signal transducers and activators of transcription) and Jak (Janus kinases) proteins are central components in the signal transduction events in hematopoietic and epithelial cells. They are rapidly activated by various cytokines, hormones, and growth factors. Upon ligand binding and cytokine receptor dimerization, Stat proteins are phosphorylated on(More)
BACKGROUND Aberrant activities of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathways have been implicated in the development and spread of various cancer entities, among them colorectal carcinoma (CRC). Transcription factors STAT3 and STAT1, both downstream effectors of interleukin (IL)-6 and its receptor, are(More)
The dual role of glycolytic enzymes in cytosol-located metabolic processes and in cell surface-mediated functions with an influence on virulence is described for various micro-organisms. Cell wall-less bacteria of the class Mollicutes including the common human pathogen Mycoplasma pneumoniae possess a reduced genome limiting the repertoire of virulence(More)
STAT3 (Signal Transducer and Activator of Transcription 3) is persistently activated in about 90% of colorectal car-cinoma (CRC) cases. However, CRC cell lines show variability in their degree of constitutive and cytokine-inducible STAT3 tyrosine phosphorylation. We have employed both surgical biopsies from CRC patients and a large collection of permanent(More)
  • 1