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Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while retaining albumin and large proteins. TheExpand
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Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9
OBJECTIVE Class IIa histone deacetylases (HDACs) belong to a large family of enzymes involved in protein deacetylation and play a role in regulating gene expression and cell differentiation.Expand
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Nuclear Factor Erythroid 2-Related Factor 2 Drives Podocyte-Specific Expression of Peroxisome Proliferator-Activated Receptor γ Essential for Resistance to Crescentic GN.
Necrotizing and crescentic rapidly progressive GN (RPGN) is a life-threatening syndrome characterized by a rapid loss of renal function. Evidence suggests that podocyte expression of theExpand
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Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in rats
Aims/hypothesisPancreatic cell development is a tightly controlled process. Although information is available regarding the mesodermal signals that control pancreatic development, little is knownExpand
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Speci fi c Control of Pancreatic Endocrine band d-Cell Mass by Class IIa Histone Deacetylases HDAC 4 , HDAC 5 , and HDAC 9
RESULTS—We show that class IIa HDAC4, -5, and -9 have an unexpected restricted expression in the endocrine band d-cells of the pancreas. Analyses of the pancreas of class IIa HDAC mutant miceExpand
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Abstract 3810: Establishment of an in vitro assay that phenocopies tumor response to PARP inhibitors in vivo
Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have recently emerged as therapeutic options for patients with homologous recombination-deficient (HRD) breast or ovarian cancer, twoExpand