Kathleen E. Wray

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Title: Estrogen and Soy Isoflavonoids Decrease Sensitivity of Medulloblastoma and Central Nervous System Primitive Neuroectodermal Tumor Cells to Chemotherapeutic Cytotoxicity Authors: Scott Belcher (smbelch2@ncsu.edu) Caleb Burton (cburton@u.northwestern.edu) Clifford Cookman (cookmacj@mail.uc.edu) Michelle Kirby (kirby_mich@yahoo.com) Gabriel Miranda(More)
Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrogens are mediated through ERβ and insulin-like growth factor 1 signaling to inhibit caspase 3 activity and reduce tumor cell apoptosis. The objective(More)
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