Kathleen E. Tucker

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Purpose: The role of assisted hatching in good-prognosis IVF patients was evaluated in a prospective, randomized, controlled pilot study, which was followed by a retrospective observational series. Methods: After assisted hatching was proved successful in a mouse embryo study, 20 good-prognosis IVF patients were randomly assigned to either assisted hatching(More)
OBJECTIVES To determine if low-dose estrogen replacement can be added to GnRH agonist therapy after three months to reduce hypoestrogenic symptoms while allowing continued relief of pain in patients with endometriosis. MATERIALS AND METHODS Thirteen women with endometriosis and pain were treated with six months of leuprolide acetate in a prospective,(More)
OBJECTIVE To determine reproductive sequelae in female rats after in utero and lactational dietary exposure to genistein. DESIGN Experimental animal study. SETTING University laboratory. ANIMAL(S) Sprague Dawley rats. INTERVENTION(S) Pregnant rats were fed control rat chow or rat chow incorporated with genistein (approximately 50 microg/d) beginning(More)
Three-week-old piglets were used to study the effects of short-term fasting on jejunal ion transport. A 48-h fast significantly reduced mucosal weight, villus height, and crypt depth. Fasting increased basal short-circuit current (Isc), which reflects active ion transport, and total tissue conductance (Gt) of muscle-stripped jejunal sheets mounted in Ussing(More)
Purpose: Our purpose was to determine the effect of Synthetic Serum Substitute (SSS) versus serum supplementation on fertilization rates and subsequent development of embryos from patients undergoing IVF. Procedure: Experiment I compared the effects of SSS to human serum on mouse embryo development. Two hundred one-cell B6D2F1 mouse embryos were cultured in(More)
OBJECTIVE To determine if a novel, preprogrammed, unmonitored stimulation protocol could reduce the cost of assisted reproductive technology (ART) without compromising outcome or safety. DESIGN Prospective, nonrandomized study of unmonitored ART versus traditional monitoring. SETTING University ART program. PATIENT(S) Infertile women aged < 39 years,(More)
OBJECTIVE To determine if extended treatment with doxycycline before and after an in vitro fertilization (IVF) procedure can minimize the detrimental effect of a hydrosalpinx. DESIGN Retrospective analysis. SETTING University IVF program. PATIENT(S) Patients undergoing IVF, including 17 with a hydrosalpinx, 25 with adhesions or proximal tubal(More)
OBJECTIVE To determine if a fixed-dose stimulation protocol with monitoring limited to a single ultrasound can provide acceptable outcomes in assisted reproduction technologies (ART) procedures in appropriately selected patients. DESIGN Prospective study of all minimally monitored ART cycles from 1996 through 1998. SETTING University ART program. (More)
BACKGROUND Women with normogonadotrophic normo-estrogenic oligomenorrhoea often disclose a variety of clinical symptoms. Many of these individuals are obese with features of pseudo-hypercortisolism. In the current study, 11-deoxycortisol and cortisol concentrations were determined in this group and compared with ovulatory controls. METHODS AND RESULTS(More)
The objective of this study was to determine the effects of neonatal exposure to phytoestrogens on male reproductive function as adults. Male rats were injected either with 100 micrograms coumestrol or DMSO (controls) daily during their first 5 d of life. Pituitary gland, testes, sex accessory organs, and blood were collected on d 60 of life. Serum(More)