Kathleen D. Hartman

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3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.

Robert I Glazer, Kathleen D. Hartman, +4 authors Victor E. Marquez
Biochemical and biophysical research…
1986

3-Deazaneplanocin, a new carbocyclic analog of adenosine, was synthesized as an inhibitor of S-adenosylhomocysteine hydrolase. The Ki of 3-deazaneplanocin for a purified hamster liver preparation of… (More)

Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

Yves Pommier, Donna Kerrigan, Kathleen D. Hartman, Robert I Glazer
The Journal of biological chemistry
1990

The influence of mammalian DNA topoisomerase I phosphorylation on enzyme activity has been investigated. Dephosphorylation by calf intestine alkaline phosphatase abolished the DNA relaxing activity… (More)

Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction.

Constance J. Glover, Kathleen D. Hartman, Ronald L. Felsted
The Journal of biological chemistry
1997

N-Myristoyltransferase (NMT) catalyzes the cotranslational acylation with myristic acid of the NH2-terminal glycines of a number of cellular and viral proteins. Most of the in vitro NMT activity… (More)

The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.

Robert I Glazer, Kathleen D. Hartman
Molecular pharmacology
1980

The effect of 5-fluorouracil on the synthesis, methylation and its incorporation into low molecular weight nuclear RNA was studied in L1210 cells in vitro . 5-Fluorouracil was incorporated into high… (More)

Lymphatic absorption and tissue disposition of liposome-entrapped [14C]adriamycin following intraperitoneal administration to rats.

Ricardo Jerome Parker, Kathleen D. Hartman, Susan M. Sieber
Cancer research
1981

The lymphatic absorption and tissue distribution of free [14C]Adriamycin, "empty" [3H]liposomes, free [14C]Adriamycin plus empty [3H]liposomes, and [14C]Adriamycin entrapped into [3H]liposomes have… (More)

Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine.

Robert I Glazer, Michal Becker Cohen, Kathleen D. Hartman, Marian C. Knode, Morton Lim, Victor E. Marquez
Biochemical pharmacology
1986

The effects of the cyclopentenyl (cCyd) and cyclopentyl (carbodine) analogues of cytidine on differentiation, and nucleic acid and nucleotide biosynthesis, were examined in the human promyelocytic… (More)

9-Deazaadenosine. Cytocidal activity and effects on nucleic acids and protein synthesis in human colon carcinoma cells in culture.

Robert I Glazer, Kathleen D. Hartman, Marian C. Knode
Molecular pharmacology
1983

The effect of 9-deazaadenosine (c9Ado) on cell lethality and the synthesis of nucleic acids was investigated in human colon carcinoma cell line HT-29. c9Ado produced a rapid threshold-exponential… (More)

In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.

Robert I Glazer, Kathleen D. Hartman
Molecular pharmacology
1983

Total mRNA from human colon carcinoma cell line HT-29 treated with either 5-fluorouracil or 5-fluorouridine was assessed in vitro in a reticulocyte lysate translation system. Under conditions of… (More)

Protein kinase C-γ is present in adriamycin resistant HL-60 leukemia cells

Abstract The isoform pattern of protein kinase C (PKC) was examined in wild-type and Adriamycin-resistant ( HL-60 AR ) HL-60 leukemia cells. Analyses were carried out by immunoblotting with mouse… (More)

Protein N-myristoylation as a chemotherapeutic target for cancer.

Ronald L. Felsted, Constance J. Glover, Kathleen D. Hartman
Journal of the National Cancer Institute
1995

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