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Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.
- Y. Pommier, D. Kerrigan, K. D. Hartman, R. Glazer
- Biology, Medicine
- The Journal of biological chemistry
- 5 June 1990
The influence of mammalian DNA topoisomerase I phosphorylation on enzyme activity has been investigated. Dephosphorylation by calf intestine alkaline phosphatase abolished the DNA relaxing activity… Expand
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
- R. Glazer, K. D. Hartman, +4 authors V. Marquez
- Biology, Medicine
- Biochemical and biophysical research…
- 13 March 1986
3-Deazaneplanocin, a new carbocyclic analog of adenosine, was synthesized as an inhibitor of S-adenosylhomocysteine hydrolase. The Ki of 3-deazaneplanocin for a purified hamster liver preparation of… Expand
Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine.
- R. Glazer, M. Cohen, K. D. Hartman, M. Knode, M. Lim, V. Marquez
- Chemistry, Medicine
- Biochemical pharmacology
- 1 June 1986
The effects of the cyclopentenyl (cCyd) and cyclopentyl (carbodine) analogues of cytidine on differentiation, and nucleic acid and nucleotide biosynthesis, were examined in the human promyelocytic… Expand
Human N-Myristoyltransferase Amino-terminal Domain Involved in Targeting the Enzyme to the Ribosomal Subcellular Fraction*
- C. J. Glover, K. D. Hartman, R. L. Felsted
- Biology, Medicine
- The Journal of Biological Chemistry
- 7 November 1997
N-Myristoyltransferase (NMT) catalyzes the cotranslational acylation with myristic acid of the NH2-terminal glycines of a number of cellular and viral proteins. Most of the in vitro NMT activity… Expand
Lymphatic absorption and tissue disposition of liposome-entrapped [14C]adriamycin following intraperitoneal administration to rats.
The lymphatic absorption and tissue distribution of free [14C]Adriamycin, "empty" [3H]liposomes, free [14C]Adriamycin plus empty [3H]liposomes, and [14C]Adriamycin entrapped into [3H]liposomes have… Expand
The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.
The effect of 5-fluorouracil on the synthesis, methylation and its incorporation into low molecular weight nuclear RNA was studied in L1210 cells in vitro . 5-Fluorouracil was incorporated into high… Expand
9-Deazaadenosine. Cytocidal activity and effects on nucleic acids and protein synthesis in human colon carcinoma cells in culture.
The effect of 9-deazaadenosine (c9Ado) on cell lethality and the synthesis of nucleic acids was investigated in human colon carcinoma cell line HT-29. c9Ado produced a rapid threshold-exponential… Expand
In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.
Total mRNA from human colon carcinoma cell line HT-29 treated with either 5-fluorouracil or 5-fluorouridine was assessed in vitro in a reticulocyte lysate translation system. Under conditions of… Expand
Protein kinase C-γ is present in adriamycin resistant HL-60 leukemia cells
The isoform pattern of protein kinase C (PKC) was examined in wild-type and Adriamycin-resistant (HL-60/AR) HL-60 leukemia cells. Analyses were carried out by immunoblotting with mouse monoclonal… Expand
Analysis of the effect of 5-fluorouracil on the synthesis and translation of polysomal poly(A)RNA from Ehrlich ascites cells.
The effects of 5-fluorouracil on the synthesis and translation in vitro of polyadenylic acid-containing polysomal RNA [poly(A)RNA] were studied in Ehrlich ascites cells incubated in vitro. Exposure… Expand