Kathleen Carole Barnes

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Kevin G. Becker, Kathleen Carole Barnes, Tiffani J. Bright, S Alex Wang
Nature Genetics
2004

Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations

Alkes L. Price, Arti Tandon, +7 authors Simon Richard Myers
PLoS genetics
2009

Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of applications from disease mapping to learning about history. Most methods require the use of unlinked… (More)

Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.

Seunggeun Lee, Mary J. Emond, +6 authors Xihong Lin
American journal of human genetics
2012

We propose in this paper a unified approach for testing the association between rare variants and phenotypes in sequencing association studies. This approach maximizes power by adaptively using the… (More)

Cytokine modulation of atopic dermatitis filaggrin skin expression.

Michael D. Howell, Byung Eui Kim, +7 authors Donald Y. M. Leung
The Journal of allergy and clinical immunology
2009

BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene… (More)

Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations

Dara G. Torgerson, Elizabeth J. Ampleford, +72 authors Dan L. Nicolae
Nature Genetics
2011

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma… (More)

Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury.

Shui Qing Ye, Brett Simon, +10 authors Joe Gn Garcia
American journal of respiratory and critical care…
2005

Although the pathogenic and genetic basis of acute lung injury (ALI) remains incompletely understood, the identification of novel ALI biomarkers holds promise for unique insights. Expression… (More)

Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis

Mark M. Wurfel, Anthony C Gordon, +23 authors Thomas R. Martin
American journal of respiratory and critical care…
2008

RATIONALE Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in… (More)

The local and systemic inflammatory transcriptome after acute kidney injury.

Dmitry N. Grigoryev, Manchang Liu, Heitham T. Hassoun, Chris Cheadle, Kathleen Carole Barnes, Hamid Rabb
Journal of the American Society of Nephrology…
2008

Studies in humans and animal models have demonstrated that acute kidney injury (AKI) has a significant effect on the function of extrarenal organs. The combination of AKI and lung dysfunction is… (More)

Variants of DENND1B associated with asthma in children.

Patrick Sleiman, James H. Flory, +39 authors Hakon Hakonarson
The New England journal of medicine
2010

BACKGROUND Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown. METHODS We carried out a… (More)

Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.

Renate G. Nickel, Vincenzo Casolaro, +12 authors Steven K Huang
Journal of immunology
2000

Up-regulation of C-C chemokine expression characterizes allergic inflammation and atopic diseases. A functional mutation in the proximal promoter of the RANTES gene has been identified, which results… (More)

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