Katherine T. Zhang

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Timely molecular diagnosis of RB1 mutations enables earlier treatment, lower risk, and better health outcomes for patients with retinoblastoma; empowers families to make informed family-planning decisions; and costs less than conventional surveillance. However, complexity has hindered clinical implementation of molecular diagnosis. The majority of RB1(More)
The RB1 gene mutation detection rate in 1,020 retinoblastoma families was increased by the use of highly sensitive allele specific-PCR (AS-PCR) to detect low-level mosaicism for 11 recurrent RB1 CGA>TGA nonsense mutations. For bilaterally affected probands, AS-PCR increased the RB1 mutation detection sensitivity from 92.6% to 94.8%. Both RB1 oncogenic(More)
BACKGROUND We examine the potential prognostic and predictive roles of EGFR variant III mutation, EGFR gene copy number (GCN), human papillomavirus (HPV) infection, c-MET and p16INK4A protein expression in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). METHODS We analyzed the archival tumor specimens of 53 patients who(More)
We have analyzed RNA from retinoblastoma patients and unaffected carriers with various RB1 gene mutations to determine the patterns of missplicing and associations with phenotypic expression. Most sequence alterations in or in the neighborhood of conserved splice signals that we tested resulted in simple exon skipping (15 mutations) or intron inclusion (new(More)
In this paper the application of a novel non-contact GBInSAR sensor to the measurement of daily deformations of an arch-gravity dam is described. The sensor, named IBIS, is a Ku-band interferometric radar sensor apt to simultaneously monitor the displacement response of several points belonging to a large structure. Moreover, the possibility of scanning the(More)
We are responding to a letter that appeared in your recent issue [1], which contains a number of major inaccuracies regarding retinoblastoma. Similar speculations and misleading conclusions can be found in two previous papers by the same first author [2,3]. We feel that we can provide enough evidence and expertise from our own work to challenge such(More)
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