Katherine Mancuso

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Color has become a premier model system for understanding how information is processed by neural circuits, and for investigating the relationships among genes, neural circuits, and perception. Both the physical stimulus for color and the perceptual output experienced as color are quite well characterized, but the neural mechanisms that underlie the(More)
Red-green colour blindness, which results from the absence of either the long- (L) or the middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here we explore the possibility of curing colour blindness using gene therapy in experiments on adult monkeys that had been colour blind since birth. A third type(More)
Recently, molecular biological techniques have presented new opportunities for addressing questions concerning the neural mechanisms involved in color coding, thereby rousing renewed interest in animal color vision testing. We have modified a computer-based assessment tool, the Cambridge Colour Test, to make it suitable for use with animals. Here, the(More)
In 1993, DeValois and DeValois proposed a 'multi-stage color model' to explain how the cortex is ultimately able to deconfound the responses of neurons receiving input from three cone types in order to produce separate red-green and blue-yellow systems, as well as segregate luminance percepts (black-white) from color. This model extended the biological(More)
Recombinant adeno-associated virus (rAAV) is a promising vector for gene therapy of photoreceptor-based diseases. Previous studies have demonstrated that rAAV serotypes 2 and 5 can transduce both rod and cone photoreceptors in rodents and dogs, and it can target rods, but not cones in primates. Here we report that using a human cone-specific enhancer and(More)
Rayleigh match data were modeled with the aim of explaining the locations of match midpoints and matching ranges, both in normal trichromats and in subjects with congenital color deficiency. Model parameters included the wavelength of peak sensitivity of cone photopigments, the effective photopigment optical density, and the noise amplitude in the red-green(More)
Delivery of foreign opsin genes to cone photoreceptors using recombinant adeno-associated virus (rAAV) is a potential tool for studying the basic mechanisms underlying cone based vision and for treating vision disorders. We used an in vivo retinal imaging system to monitor, over time, expression of virally-delivered genes targeted to cone photoreceptors in(More)
[PDF] [Abstract] , June, 2009; 15 (3): 274-290. Neuroscientist Bevil R. Conway Color Vision, Cones, and Color-Coding in the Cortex [PDF] [Full Text] [Abstract] , August, 4 2010; 30 (31): 10337-10350. J. Neurosci. Elizabeth N. Johnson, Stephen D. Van Hooser and David Fitzpatrick The Representation of S-Cone Signals in Primary Visual Cortex [PDF] [Full(More)
for Chapter A MULTI-STAGE COLOR MODEL REVISITED: IMPLICATIONS FOR A GENE THERAPY CURE FOR RED-GREEN COLORBLINDNESS Katherine Mancuso, Matthew C. Mauck, James A. Kuchenbecker, Maureen Neitz, and Jay Neitz In 1993, DeValois and DeValois proposed a “multi-stage color model” to explain how the cortex is ultimately able to deconfound the responses of neurons(More)
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