Katherine M. Leith

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Cysteine metabolism with the subsequent release of anionic thiols has been shown to be involved in yeast cell morphogenesis of the dimorphic, pathogenic fungus Histoplasma capsulatum. Following transfer to fresh medium, intracellular thiol levels during the initial 2–4 h appear to determine the eventual growth form. Mild oxidative stress induced by paraquat(More)
Pancreatic polypeptide (PP) is synthesized as an amino-terminal moiety of a precursor peptide and is released into plasma during stimulation as an amidated hormone (PP1-36). The purpose of this investigation was to ascertain the immunoreactive forms of PP in human plasma using HPLC chromatographic technique. Plasma was obtained from five normal volunteers(More)
PURPOSE Prognostic markers that identify patients with stage II colon cancers who are at the risk of recurrence are essential to personalize therapy. We evaluated the potential of GIV/Girdin as a predictor of recurrence risk in such patients. EXPERIMENTAL DESIGN Expression of full-length GIV was evaluated by IHC using a newly developed mAb together with a(More)
Pancreatic polypeptide (PP) receptors have been identified and characterized on the basolateral membranes (BLM) of canine intestinal mucosa. The present study was designed to ascertain the structural requirements of the PP molecule for binding to its receptor. A radioreceptor assay using purified BLM was employed to elucidate receptors specific to PPs of(More)
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