Katherine L. Mitchell

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Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the pathways mediating RGC death and identify targets for the development of neuroprotective drugs, we developed a high-throughput RNA interference screen with primary RGCs and used(More)
Retinal ischemia plays a critical role in multiple vision-threatening diseases and leads to death of retinal neurons, particularly ganglion cells. Oxidative stress plays an important role in this ganglion cell loss. Nrf2 (NF-E2-related factor 2) is a major regulator of the antioxidant response, and its role in the retina is increasingly appreciated. We(More)
The origin of the turtle shell over 200 million years ago greatly modified the amniote body plan, and the morphological plasticity of the shell has promoted the adaptive radiation of turtles. The shell, comprising a dorsal carapace and a ventral plastron, is a layered structure formed by basal endochondral axial skeletal elements (ribs, vertebrae) and(More)
PURPOSE To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone, enalapril, or no drug to test effects of inhibiting(More)
OBJECTIVES This study aimed to compare costs of caring for people with dementia in domiciliary and residential settings, central England. METHODS A cohort of people with dementia was recruited during a hospital stay 2008-2010. Data were collected by interview at baseline, and 6- and 12-month follow-up, covering living situation (own home with or without(More)
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The Active Denial System (ADS) is a non-lethal weapons technology that uses millimeter-wave directed energy to arrest and deter potential adversaries. Developed by the Air Force Research Laboratory and the Department of Defense's Non-Lethal Weapons Program, ADS provides U.S. forces with a highly effective means of responding to potential threats while also(More)
We recently discovered that young infants learn a new association better in the presence of a prior association than when they learn it alone - a phenomenon we call associative potentiation. When 6-month-olds observed actions modeled on a puppet (remembered for 1 day) in the presence of a toy train they had learned to activate (remembered for 2 weeks), they(More)
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