Katherine L. Helms

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Nrf2 is a key transcription factor that regulates cellular redox and defense responses. However, permanent Nrf2 activation in human lung carcinomas promotes pulmonary malignancy and chemoresistance. We tested the hypothesis that Nrf2 has cell survival properties and lack of Nrf2 suppresses chemically-induced pulmonary neoplasia by treating Nrf2(+/+) and(More)
The mechanisms which regulate HSC regeneration following myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow (BM) serum of mice bearing deletion of Bak and Bax in Tie2 + cells (Tie2Cre;Bak1 −/− ;Bax fl/− mice), which displayed radioprotection of the HSC pool and 100% survival(More)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational toxicants, which are a major human health concern in the U.S. and abroad. Previous research has focused on the genotoxic events caused by high molecular weight PAHs, but not on non-genotoxic events elicited by low molecular weight PAHs. We used an isomeric pair of low(More)
A viscoelastic cohesive zone model is employed within the framework of a finite element code to analyze a two-phase viscoelastic particle-reinforced composite material consisting of a relatively stiff aggregate embedded in a copolymer binder. The composite of interest, LX17, is noted to have a very large aggregate volume fraction and as such, aggregate(More)
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