Katherine L Fowler

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The effect of infrarenal cross-clamping of the aorta on regional splanchnic and renal circulations was studied in seven dogs. Regional blood flow was determined with differentially labeled microspheres (9 and 15 micron in diameter) that were injected simultaneously into the left atrium. Blood flow was measured 30 minutes after surgical preparation was(More)
Labeled microspheres, 15 microns in diameter, were used to determine cardiac output and regional blood flow response to cross-clamping of the midthoracic aorta and subsequent sodium nitroprusside (SNP) infusion in 11 dogs. During aortic cross-clamping, mean arterial pressure above the occlusion (MAPa) increased 30% to 35%, mean arterial pressure below the(More)
The sympathetic neural regulation of the cerebral circulation remains controversial. The purpose of the present study was to determine how exercise modulates the simultaneous responsiveness of the cerebral and brachial circulations to 'endogenous' sympathetic activation (cold pressor test). In nine healthy subjects, heart rate (HR) and mean arterial blood(More)
o-Benzyl-p-chlorophenol (BCP) is a major household and industrial germicide. Its prechronic toxicity was evaluated in male and female F344 rats and B6C3F1 mice. Treatment was by gavage in corn oil. BCP was slightly toxic after acute oral exposure, with high mortality at 4000 and 2000 mg/kg in rats and mice. Exposure to 12 oral doses of BCP at 1000, 500,(More)
The potential thyrotoxic effect of SK&F 93479 (an H2-receptor antagonist), aminoglutethimide (AG) and glutethimide were studied by examining their effects on 125iodide uptake and organification (incorporation into thyroglobulin) in cultured thyroid cells from the pig and rat. These effects were compared with those of positive controls(More)
Exposure of rat thyroid FRTL-5 cells to high concentrations of thyroid stimulating hormone (TSH) for 24 hr in vitro activated (125)iodide but not ouabain-sensitive (86)Rb transport in the cells, whereas after 27 hr and above there were significant increases in the activity of both transporters. This was similar to results obtained in(More)
The effects of omeprazole (an H+, K+ -ATPase inhibitor) on thyroid parameters in rats have been examined. SK&F Wistar rats were dosed orally with omeprazole (up to 500 mg kg-1) or vehicle. Treatment for 7 or 14 days resulted in generally decreased plasma T3 concentrations in males (with little change or slight increases in females) and increased serum TSH(More)
Rubidium clearance and 9-micron-sphere entrapment were studied and compared in isolated intestinal preparations under various physiological conditions in 10 dogs anesthetized with intravenous pentobarbital sodium. The chosen intestinal segment was pumped with aortic blood at a constant rate and pressure of about 90-100 mmHg. The temperature of the isolated(More)
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