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IRE1-Dependent Activation of AMPK in Response to Nitric Oxide
ABSTRACT While there can be detrimental consequences of nitric oxide production at pathological concentrations, eukaryotic cells have evolved protective mechanisms to defend themselves against thisExpand
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FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide*
For many cell types, including pancreatic β-cells, nitric oxide is a mediator of cell death; paradoxically, nitric oxide can also activate pathways that promote the repair of cellular damage. In thisExpand
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Zinc induces ERK-dependent cell death through a specific Ras isoform
The effect of Zn on p53-independent cell death was examined in IIC9 embryonic fibroblasts. Despite the fact that these cells are p53-minus, Zn-mediated death occurs via an apoptotic mechanism. DeathExpand
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Repair of Nitric Oxide-damaged DNA in β-Cells Requires JNK-dependent GADD45α Expression*
Proinflammatory cytokines induce nitric oxide-dependent DNA damage and ultimately β-cell death. Not only does nitric oxide cause β-cell damage, it also activates a functional repair process. In thisExpand
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Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage.
For many cell types, including pancreatic β-cells, nitric oxide is a mediator of cell death; however, it is paradoxical that for a given cell type nitric oxide can induce both necrosis and apoptosis.Expand
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AMP-activated Protein Kinase Attenuates Nitric Oxide-induced β-Cell Death*
During the initial autoimmune response in type 1 diabetes, islets are exposed to a damaging mix of pro-inflammatory molecules that stimulate the production of nitric oxide by β-cells. Nitric oxideExpand
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Cytokine-mediated β-cell damage in PARP-1-deficient islets.
Poly(ADP)-ribose polymerase (PARP) is an abundant nuclear protein that is activated by DNA damage; once active, it modifies nuclear proteins through attachment of poly(ADP)-ribose units derived fromExpand
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Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel.
Peptide amphiphile (PA) is a peptide-based biomaterial that can self-assemble into a nanostructured gel-like scaffold, mimicking the chemical and biological complexity of natural extracellularExpand
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Science Magazine
www.sciencemag.org SCIENCE VOL 337 20 JULY 2012 295 robot future, and, most important, the crucial role of good models in science. Darwin’s Devices recounts the efforts of Long and his colleagues toExpand
Fromthe ‡ EdwardA.DoisyDepartmentofBiochemistryandMolecularBiology,St.LouisUniversitySchoolofMedicine,St.Louis, Missouri63104,the §
For many cell types, including pancreatic -cells, nitric oxide is a mediator of cell death; paradoxically, nitric oxide can also activate pathways that promote the repair of cellular damage. In thisExpand