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This paper summarizes techniques for modeling geometric properties of THUNDER actuators which arise in the fabrication process. These actuators are high performance composites comprised of layers of piezoceramics in combination with aluminum, stainless steel, brass or titanium bonded with hot-melt adhesive. During the construction process, the assembly is(More)
Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with metastatic cholangiocarcinoma contained CD4+ T helper 1 (T(H)1) cells recognizing a mutation in erbb2 interacting protein (ERBB2IP)(More)
Cancer vaccines can induce the in vivo generation of tumor Ag-specific T cells in patients with metastatic melanoma yet seldom elicit objective clinical responses. Alternatively, adoptive transfer of autologous tumor-infiltrating lymphocytes (TIL) can mediate tumor regression in 50% of lymphodepleted patients, but are logistically and technically difficult(More)
Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate cancer regression in patients with metastatic melanoma, but whether this approach can be applied to common epithelial malignancies remains unclear. In this study, we compared the phenotype and function of TILs derived from liver and lung metastases from patients with(More)
Few studies have investigated whether visual perception can influence auditory perception outside the speech domain in a way comparable to the McGurk effect. Here we used common environmental events, a wooden and a metal spoon hitting a granite surface, to test for a change in auditory perception of the spoon's material induced by an incongruent video. To(More)
Accumulating evidence suggests that the efficacy of ACT in melanoma is mediated by T cells that target somatic mutations expressed by the patients' tumors. Moreover, in one patient with metastatic epithelial (bile duct) cancer, we recently identified tumor-infiltrating Th1 cells that specifically recognized a mutation in ERBB2IP expressed by the patient's(More)
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