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Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p*
- J. Thakur, H. Arthanari, Fajun Yang, Katherine H Chau, G. Wagner, A. Näär
- BiologyJournal of Biological Chemistry
- 13 February 2009
Evidence is provided for an ancient and essential role of a Mediator co-activator subunit in regulation of fatty acid metabolism by nuclear receptor-like transcription factors in eukaryotes.
The book of opposites: the role of the nuclear receptor co-regulators in the suppression of epidermal genes by retinoic acid and thyroid hormone receptors.
It is found that in the context of specific keratin RE (KRE), co-activators and histone acetylase become co-repressors of the RA/T3 receptors in the presence of their respective ligands, thus exerting intrinsic tissue specificity.