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INTRODUCTION Breast cancer is thought to arise in mammary epithelial stem cells. There is, therefore, a large amount of interest in identifying these cells. The breast is a complex tissue consisting of two epithelial layers (an outer myoepithelial/basal layer and an inner luminal epithelial layer) as well as a large non-epithelial component (fibroblasts,(More)
The role of estrogen in promoting mammary stem cell proliferation remains controversial. It is unclear if estrogen receptor (ER)-expressing cells have stem/progenitor activity themselves or if they act in a paracrine fashion to stimulate stem cell proliferation. We have used flow cytometry to prospectively isolate mouse mammary ER-expressing epithelial(More)
BACKGROUND England has one of the highest rates of hospital death in dementia in Europe. How this has changed over time is unknown. This study aimed to analyse temporal trends in place of death in dementia over a recent ten year period. METHODS Population-based study linking Office for National Statistics mortality data with regional variables, in England(More)
BACKGROUND Studies in the United Kingdom and elsewhere have suggested inequality of hospice provision with respect to factors such as age, diagnosis and socio-economic position. How this has changed over time is unknown. AIM To describe the factors associated with inpatient hospice death in England and examine how these have changed over time. DESIGN(More)
OBJECTIVES To understand healthcare professionals' perceptions of the benefits and potential harms of integrated care pathways for end-of-life care, to inform the development of future interventions that aim to improve care of the dying. DESIGN Qualitative interview study with maximum variation sampling and thematic analysis. PARTICIPANTS 25 healthcare(More)
Palliative and end of life care is essential to healthcare systems worldwide, yet a minute proportion of research funding is spent on palliative and end of life care research. Routinely collected health and social care data provide an efficient and useful opportunity for evaluating and improving care for patients and families. There are excellent examples(More)
BACKGROUND mortality statistics are a frequently used source of information on deaths in dementia but are limited by concerns over accuracy. OBJECTIVE to investigate the frequency with which clinically diagnosed dementia is recorded on death certificates, including predictive factors. METHODS a retrospective cohort study assembled using a large mental(More)
Investigator held by Higginson and CLAHRC funding contributed to supporting authors and investigators on this project. ABSTRACT OBJECTIVE: To identify factors associated with end of life (EoL) transition from usual place of care to hospital as place of death for people aged 75 years or older (75+). DESIGN: Population-based mortality follow-back survey.(More)
(2016) Factors associated with transition from community settings to hospital as place of death for adults aged 75 years or older: a population-based mortality follow-back survey. This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you(More)