Katherine E. Niehaus

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BACKGROUND Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and rare mutations predicting drug resistance, or consistency(More)
BACKGROUND Recent studies suggest certain antiretroviral therapy (ART) drugs are associated with increases in cardiovascular disease. PURPOSE We performed a systematic review and meta-analysis to summarize the available evidence, with the goal of elucidating whether specific ART drugs are associated with an increased risk of myocardial infarction (MI). (More)
After psychological trauma, why do some only some parts of the traumatic event return as intrusive memories while others do not? Intrusive memories are key to cognitive behavioural treatment for post-traumatic stress disorder, and an aetiological understanding is warranted. We present here analyses using multivariate pattern analysis (MVPA) and a machine(More)
Clinical data management systems typically provide caregiver teams with useful information, derived from large, sometimes highly heterogeneous, data sources that are often changing dynamically. Over the last decade there has been a significant surge in interest in using these data sources, from simply re-using the standard clinical databases for event(More)
— The prevalence of antibiotic resistance in pathogens is far outpacing our ability to develop new antibiotics. This necessitates the development of diagnostic tests that can determine bacterial susceptibility. For Mycobacterium tuberculosis (MTB), this is particularly urgent given that current methods for testing susceptibility take up to two months. The(More)
Crohn's disease (CD) is a highly heterogeneous disease, with great variation in patient severity. Using supervised machine learning techniques to predict severity from common laboratory and clinical measurements, we found that high levels of C-reactive protein and low levels of lymphocytes and albumin are important predictive factors. Building upon this(More)
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